Sandbox UC 10

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== N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN ==
== N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN ==
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Dystrophin is an essential component of skeletal muscle cells. Its N-terminal domain binds to F-actin and its C terminus binds to the dystrophin-associated glycoprotein (DAG) complex in the membrane.
 
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<StructureSection load='1dq8' size='500' side='right' caption='N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN (PDB entry [[1dxx]])' scene=''>[[Image:1dxx.png|200px|left|thumb|Crystal Structure of Human dystrophin, [[1dxx]]]]Dystrophin is an essential component of skeletal muscle cells. Its N-terminal domain binds to F-actin and its C terminus binds to the dystrophin-associated glycoprotein (DAG) complex in the membrane.<scene name='1xjo/Active_site/3'>active site</scene>
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CONCLUSIONS: The dystrophin ABD structure reveals a previously uncharacterised arrangement of the CH domains within the ABD. This observation has implications for the mechanism of actin binding by dystrophin and related proteins. Examining the position of three pathogenic missense mutations within the structure suggests that they exert their effects through misfolding of the ABD, rather than through disruption of the binding to F-actin<ref>PMID 10801490</ref>[[Image:imag1gonzalo.jpg|right|200px|thumb|Comparacion de la degeneracion muscular, [[1dxx]]]]
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{{STRUCTURE_1dxx| PDB=1dxx | SIZE=400| SCENE= |right|CAPTION=N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN [[3fsp]] }}
 
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[[Image:1dxx.png|left|200px|thumb|Crystal Structure of Human dystrophin, [[1dxx]]]]
 
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[[Image:imag1gonzalo.jpg|right|200px|thumb|Comparacion de la degeneracion muscular, [[1dxx]]]]
 
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[[Image:MW_Folding_Simulations.gif|center|200px|thumb|[[1dxx]]]]
 
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<scene name='Sandbox_UC_10/Scene1/1'>Rainbow</scene>
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== Escenas ==
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{{Template:ColorKey_Amino2CarboxyRainbow}}
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<scene name='Sandbox_UC_10/Conservacion_evolutiva/1'>Zonas conservadas evolutivamente</scene>
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{{Template:ColorKey_ConSurf}}
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<scene name='Sandbox_UC_10/Conservacion_evolutiva2/2'>TextToBeDisplayed</scene>
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<scene name='Sandbox_UC_10/Escena2/1'>TextToBeDisplayed</scene>
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<scene name='Sandbox_UC_10/Scene2/1'>Estructuras secundarias</scene>
 
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</StructureSection>
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== QUIZ TIME !! ==
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<quiz display=simple>
<quiz display=simple>
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{la pregunta va aquí | Type = "[]"}
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{la pregunta va aquí |Type="[]"}
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{la pregunta va aquí | Type = "[]"}
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{la pregunta va aquí |Type="[]"}
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</Quiz>
</Quiz>
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== Referencias ==
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Ref1<ref>PMID 1234</ref>
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Ref2 <ref>PMID 12345</ref>
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<references/>
<references/>
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Current revision

N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN

N-TERMINAL ACTIN-BINDING DOMAIN OF HUMAN DYSTROPHIN (PDB entry 1dxx)

Drag the structure with the mouse to rotate


QUIZ TIME !!

1. la pregunta va aquí |Type="[]"

no.
uno.
si.

2. la pregunta va aquí |Type="[]"

no.
si.
quizás.

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Referencias

  1. ↑ Norwood FL, Sutherland-Smith AJ, Keep NH, Kendrick-Jones J. The structure of the N-terminal actin-binding domain of human dystrophin and how mutations in this domain may cause Duchenne or Becker muscular dystrophy. Structure. 2000 May 15;8(5):481-91. PMID:10801490
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