1t1t

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[[Image:1t1t.gif|left|200px]]<br /><applet load="1t1t" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1t1t" />
 
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'''Solution Structure of Kurtoxin'''<br />
 
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==About this Structure==
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==Solution Structure of Kurtoxin==
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1T1T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA].
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<StructureSection load='1t1t' size='340' side='right'caption='[[1t1t]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Parabuthus_transvaalicus Parabuthus transvaalicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T1T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1t OCA], [https://pdbe.org/1t1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t1t RCSB], [https://www.ebi.ac.uk/pdbsum/1t1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t1t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KURT_PARTR KURT_PARTR] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A. Also binds to Cav3.1/CACNA1G and Cav3.2/CACNA1H T-type calcium channels with high affinity and inhibits the channels by modifying voltage-dependent gating. Another study (PubMed:11896142) shows that it also targets neuronal high-threshold calcium channels, including P-type, N-type, and L-type calcium channels (Cav), and others that still are unidentified pharmacologically.<ref>PMID:10196582</ref> <ref>PMID:11896142</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t1t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t1t ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Parabuthus transvaalicus]]
[[Category: Parabuthus transvaalicus]]
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[[Category: Single protein]]
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[[Category: Cho EM]]
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[[Category: Cho, E M.]]
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[[Category: Eu YJ]]
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[[Category: Eu, Y J.]]
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[[Category: Kim JI]]
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[[Category: Kim, J I.]]
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[[Category: Kohno T]]
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[[Category: Kohno, T.]]
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[[Category: Lee CW]]
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[[Category: Lee, C W.]]
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[[Category: Min HJ]]
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[[Category: Min, H J.]]
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[[Category: cysteine stabilized alpha-beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:08:56 2008''
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Current revision

Solution Structure of Kurtoxin

PDB ID 1t1t

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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