4gp0

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[[Image:4gp0.png|left|200px]]
 
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{{STRUCTURE_4gp0| PDB=4gp0 | SCENE= }}
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==The crystal structure of human fascin 1 R149A K150A R151A mutant==
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<StructureSection load='4gp0' size='340' side='right'caption='[[4gp0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gp0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GP0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gp0 OCA], [https://pdbe.org/4gp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gp0 RCSB], [https://www.ebi.ac.uk/pdbsum/4gp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gp0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FSCN1_HUMAN FSCN1_HUMAN] Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.<ref>PMID:9362073</ref> <ref>PMID:9571235</ref> <ref>PMID:20137952</ref> <ref>PMID:20393565</ref>
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===The crystal structure of human fascin 1 R149A K150A R151A mutant===
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==See Also==
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*[[Fascin|Fascin]]
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{{ABSTRACT_PUBMED_23184945}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4gp0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GP0 OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, L.]]
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[[Category: Large Structures]]
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[[Category: Chen, S.]]
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[[Category: Chen L]]
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[[Category: Diaz-Avalos, R.]]
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[[Category: Chen S]]
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[[Category: Huang, F K.]]
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[[Category: Diaz-Avalos R]]
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[[Category: Huang, J.]]
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[[Category: Huang FK]]
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[[Category: Huang, X Y.]]
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[[Category: Huang J]]
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[[Category: Jakoncic, J.]]
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[[Category: Huang XY]]
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[[Category: Leo-Macias, A.]]
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[[Category: Jakoncic J]]
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[[Category: Yang, S Y.]]
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[[Category: Leo-Macias A]]
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[[Category: Zhang, J J.]]
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[[Category: Yang SY]]
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[[Category: Actin]]
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[[Category: Zhang JJ]]
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[[Category: Actin bundling protein]]
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[[Category: Actin-binding]]
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[[Category: Beta-trefoil]]
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[[Category: Cancer]]
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[[Category: Cell migration]]
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[[Category: Metastasis]]
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[[Category: Phosphoprotein]]
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[[Category: Protein binding]]
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Current revision

The crystal structure of human fascin 1 R149A K150A R151A mutant

PDB ID 4gp0

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