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4eox

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[[Image:4eox.png|left|200px]]
 
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{{STRUCTURE_4eox| PDB=4eox | SCENE= }}
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==X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor==
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<StructureSection load='4eox' size='340' side='right'caption='[[4eox]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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===X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4eox]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_R6 Streptococcus pneumoniae R6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EOX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22579486}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.783&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S5:N-BENZOYL-1-[(2R)-3-CYCLOPENTYL-2-{[FORMYL(HYDROXY)AMINO]METHYL}PROPANOYL]-L-PROLINAMIDE'>0S5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eox OCA], [https://pdbe.org/4eox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eox RCSB], [https://www.ebi.ac.uk/pdbsum/4eox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eox ProSAT]</span></td></tr>
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[[4eox]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae_r6 Streptococcus pneumoniae r6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EOX OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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<ref group="xtra">PMID:022579486</ref><references group="xtra"/>
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__TOC__
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[[Category: Peptide deformylase]]
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</StructureSection>
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[[Category: Streptococcus pneumoniae r6]]
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[[Category: Large Structures]]
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[[Category: Campobasso, N.]]
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[[Category: Streptococcus pneumoniae R6]]
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[[Category: Ward, P.]]
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[[Category: Campobasso N]]
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[[Category: Alpha-beta]]
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[[Category: Ward P]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Peptide deformylase metal ion binding]]
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Current revision

X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor

PDB ID 4eox

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