4gfd

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[[Image:4gfd.png|left|200px]]
 
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{{STRUCTURE_4gfd| PDB=4gfd | SCENE= }}
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==Thymidylate kinase (TMK) from S. Aureus in complex with TK-666==
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<StructureSection load='4gfd' size='340' side='right'caption='[[4gfd]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gfd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GFD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0YB:2-(3-BROMOPHENOXY)-4-{(1R)-3,3-DIMETHYL-1-[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]BUTYL}BENZOIC+ACID'>0YB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gfd OCA], [https://pdbe.org/4gfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gfd RCSB], [https://www.ebi.ac.uk/pdbsum/4gfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gfd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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===Thymidylate kinase (TMK) from S. Aureus in complex with TK-666===
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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{{ABSTRACT_PUBMED_22908966}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4gfd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_n315 Staphylococcus aureus subsp. aureus n315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GFD OCA].
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[[Category: Staphylococcus aureus subsp. aureus N315]]
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[[Category: Staphylococcus aureus subsp. aureus n315]]
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[[Category: Keating T]]
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[[Category: DTMP kinase]]
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[[Category: Martinez-Botella G]]
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[[Category: Keating, T.]]
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[[Category: Olivier NB]]
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[[Category: Martinez-Botella, G.]]
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[[Category: Olivier, N B.]]
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[[Category: Kinase]]
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[[Category: Soluble]]
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[[Category: Thymidine monphosphate]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Thymidylate kinase (TMK) from S. Aureus in complex with TK-666

PDB ID 4gfd

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