4ejh

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[[Image:4ejh.png|left|200px]]
 
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{{STRUCTURE_4ejh| PDB=4ejh | SCENE= }}
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==Human Cytochrome P450 2A13 in complex with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)==
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<StructureSection load='4ejh' size='340' side='right'caption='[[4ejh]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ejh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EJH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QA:4-[METHYL(NITROSO)AMINO]-1-(PYRIDIN-3-YL)BUTAN-1-ONE'>0QA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ejh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ejh OCA], [https://pdbe.org/4ejh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ejh RCSB], [https://www.ebi.ac.uk/pdbsum/4ejh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ejh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP2AD_HUMAN CP2AD_HUMAN] Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.<ref>PMID:18779312</ref>
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===Human Cytochrome P450 2A13 in complex with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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{{ABSTRACT_PUBMED_22700965}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4ejh]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EJH OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Large Structures]]
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[[Category: DeVore, N M.]]
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[[Category: DeVore NM]]
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[[Category: Scott, E E.]]
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[[Category: Scott EE]]
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[[Category: Cyp2a13]]
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[[Category: Cytochrome p450 2a13]]
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[[Category: Drug metabolism]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Heme protein]]
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[[Category: Membrane]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: P450 2a13]]
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[[Category: Xenobiotic metabolism]]
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Current revision

Human Cytochrome P450 2A13 in complex with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

PDB ID 4ejh

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