3tc3
From Proteopedia
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| - | [[Image:3tc3.png|left|200px]] | ||
| - | + | ==Crystal Structure of SacUVDE== | |
| + | <StructureSection load='3tc3' size='340' side='right'caption='[[3tc3]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius_DSM_639 Sulfolobus acidocaldarius DSM 639]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TC3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tc3 OCA], [https://pdbe.org/3tc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tc3 RCSB], [https://www.ebi.ac.uk/pdbsum/3tc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tc3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q4J9T1_SULAC Q4J9T1_SULAC] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Repairing damaged DNA is essential for an organism's survival. UV damage endonuclease (UVDE) is a DNA-repair enzyme that can recognize and incise different types of damaged DNA. We present the structure of Sulfolobus acidocaldarius UVDE on its own and in a pre-catalytic complex with UV-damaged DNA containing a 6-4 photoproduct showing a novel 'dual dinucleotide flip' mechanism for recognition of damaged dipyrimidines: the two purines opposite to the damaged pyrimidine bases are flipped into a dipurine-specific pocket, while the damaged bases are also flipped into another cleft. | ||
| - | + | UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions.,Meulenbroek EM, Peron Cane C, Jala I, Iwai S, Moolenaar GF, Goosen N, Pannu NS Nucleic Acids Res. 2012 Dec 11. PMID:23221644<ref>PMID:23221644</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3tc3" style="background-color:#fffaf0;"></div> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Endonuclease 3D structures|Endonuclease 3D structures]] |
| - | [[Category: Sulfolobus acidocaldarius | + | == References == |
| - | [[Category: Goosen | + | <references/> |
| - | [[Category: Jala | + | __TOC__ |
| - | [[Category: Meulenbroek | + | </StructureSection> |
| - | [[Category: Moolenaar | + | [[Category: Large Structures]] |
| - | [[Category: Pannu | + | [[Category: Sulfolobus acidocaldarius DSM 639]] |
| - | + | [[Category: Goosen N]] | |
| - | + | [[Category: Jala I]] | |
| - | + | [[Category: Meulenbroek EM]] | |
| + | [[Category: Moolenaar GF]] | ||
| + | [[Category: Pannu NS]] | ||
Current revision
Crystal Structure of SacUVDE
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