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1t3p
From Proteopedia
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| - | [[Image:1t3p.gif|left|200px]]<br /><applet load="1t3p" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1t3p, resolution 1.60Å" /> | ||
| - | '''Half-sandwich arene ruthenium(II)-enzyme complex'''<br /> | ||
| - | == | + | ==Half-sandwich arene ruthenium(II)-enzyme complex== |
| + | <StructureSection load='1t3p' size='340' side='right'caption='[[1t3p]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1t3p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3P FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU7:PARA-CYMENE+RUTHENIUM+CHLORIDE'>RU7</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3p OCA], [https://pdbe.org/1t3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3p RCSB], [https://www.ebi.ac.uk/pdbsum/1t3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3p_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3p ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
The 1.6 [Angstrom] X-ray crystal structure of [(eta(6)-p-cymene)Ru(lysozyme)Cl(2)], the first of a half-sandwich complex of a protein, shows selective ruthenation of Nepsilon of the imidazole ring of His15. | The 1.6 [Angstrom] X-ray crystal structure of [(eta(6)-p-cymene)Ru(lysozyme)Cl(2)], the first of a half-sandwich complex of a protein, shows selective ruthenation of Nepsilon of the imidazole ring of His15. | ||
| - | + | Half-sandwich arene ruthenium(II)-enzyme complex.,McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang F, Walkinshaw MD, Sadler PJ Chem Commun (Camb). 2004 Aug 21;(16):1786-7. Epub 2004 Jul 27. PMID:15306883<ref>PMID:15306883</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1t3p" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gallus gallus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fishburne K]] | ||
| + | [[Category: Habtemariam A]] | ||
| + | [[Category: Hunter TM]] | ||
| + | [[Category: McNae IW]] | ||
| + | [[Category: Melchart M]] | ||
| + | [[Category: Sadler PJ]] | ||
| + | [[Category: Walkinshaw MD]] | ||
| + | [[Category: Wang F]] | ||
Current revision
Half-sandwich arene ruthenium(II)-enzyme complex
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