4ehq
From Proteopedia
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| - | [[Image:4ehq.png|left|200px]] | ||
| - | + | ==Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode== | |
| + | <StructureSection load='4ehq' size='340' side='right'caption='[[4ehq]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ehq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9005Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GBL:GAMMA-BUTYROLACTONE'>GBL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehq OCA], [https://pdbe.org/4ehq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehq RCSB], [https://www.ebi.ac.uk/pdbsum/4ehq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CALM1_RAT CALM1_RAT] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2.[UniProtKB:P62158] | ||
| - | === | + | ==See Also== |
| - | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Homo sapiens]] | |
| - | [[ | + | [[Category: Large Structures]] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Birnbaumer | + | [[Category: Birnbaumer L]] |
| - | [[Category: DeRose | + | [[Category: DeRose EF]] |
| - | [[Category: Liu | + | [[Category: Liu Y]] |
| - | [[Category: London | + | [[Category: London RE]] |
| - | [[Category: Mueller | + | [[Category: Mueller GA]] |
| - | [[Category: Sobhany | + | [[Category: Sobhany M]] |
| - | [[Category: Zhang | + | [[Category: Zhang Y]] |
| - | [[Category: Zheng | + | [[Category: Zheng X]] |
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Current revision
Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+/Calmodulin Displays a Unique Binding Mode
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Categories: Homo sapiens | Large Structures | Rattus norvegicus | Birnbaumer L | DeRose EF | Liu Y | London RE | Mueller GA | Sobhany M | Zhang Y | Zheng X
