4fxi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:35, 14 March 2024) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4fxi.png|left|200px]]
 
-
{{STRUCTURE_4fxi| PDB=4fxi | SCENE= }}
+
==Crystal structure of the isolated E. coli RelE toxin, P21 form==
-
 
+
<StructureSection load='4fxi' size='340' side='right'caption='[[4fxi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
===Crystal structure of the isolated E. coli RelE toxin, P21 form===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4fxi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kha 3kha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXI FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_22981948}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8003&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxi OCA], [https://pdbe.org/4fxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxi RCSB], [https://www.ebi.ac.uk/pdbsum/4fxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxi ProSAT]</span></td></tr>
-
[[4fxi]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3kha 3kha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXI OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/RELE_ECOLI RELE_ECOLI] Toxic component of a toxin-antitoxin (TA) module. A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). Acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits. Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is inhibited by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow or die in presence of bactericidal agent and are largely responsible for high levels of biofilm tolerance to antimicrobials). Acts with RelB as a corepressor of relBE transcription.<ref>PMID:9767574</ref> <ref>PMID:11274135</ref> <ref>PMID:11717402</ref> <ref>PMID:12123459</ref> <ref>PMID:12526800</ref> <ref>PMID:19707553</ref> Seems to be a principal mediator of cell death in liquid media.<ref>PMID:9767574</ref> <ref>PMID:11274135</ref> <ref>PMID:11717402</ref> <ref>PMID:12123459</ref> <ref>PMID:12526800</ref> <ref>PMID:19707553</ref>
-
<ref group="xtra">PMID:020005802</ref><references group="xtra"/>
+
== References ==
-
[[Category: Escherichia coli k-12]]
+
<references/>
-
[[Category: Boggild, A.]]
+
__TOC__
-
[[Category: Brodersen, D E.]]
+
</StructureSection>
-
[[Category: Sofos, N.]]
+
[[Category: Escherichia coli K-12]]
-
[[Category: B-me on cys50]]
+
[[Category: Large Structures]]
-
[[Category: Nuclease]]
+
[[Category: Boggild A]]
-
[[Category: Relb]]
+
[[Category: Brodersen DE]]
-
[[Category: Ribosome]]
+
[[Category: Sofos N]]
-
[[Category: Stress response]]
+
-
[[Category: Toxin]]
+
-
[[Category: Toxin/antitoxin system]]
+
-
[[Category: Translational control]]
+

Current revision

Crystal structure of the isolated E. coli RelE toxin, P21 form

PDB ID 4fxi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4fxi"
Personal tools