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3uyj
From Proteopedia
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| - | [[Image:3uyj.png|left|200px]] | ||
| - | + | ==Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG== | |
| + | <StructureSection load='3uyj' size='340' side='right'caption='[[3uyj]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3uyj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">JMJD5, KDM8 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyj OCA], [https://pdbe.org/3uyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyj RCSB], [https://www.ebi.ac.uk/pdbsum/3uyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. | ||
| - | === | + | ==See Also== |
| - | + | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Human]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Li, H | + | [[Category: Li, H]] |
| - | [[Category: Su, X | + | [[Category: Su, X]] |
[[Category: Demethylase]] | [[Category: Demethylase]] | ||
[[Category: Jellyroll-like all beta fold]] | [[Category: Jellyroll-like all beta fold]] | ||
[[Category: Nuclear]] | [[Category: Nuclear]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Current revision
Crystal structure of JMJD5 catalytic core domain in complex with nickle and alpha-KG
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