4gu4

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[[Image:4gu4.png|left|200px]]
 
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{{STRUCTURE_4gu4| PDB=4gu4 | SCENE= }}
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==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose==
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<StructureSection load='4gu4' size='340' side='right'caption='[[4gu4]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gu4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GU4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu4 OCA], [https://pdbe.org/4gu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gu4 RCSB], [https://www.ebi.ac.uk/pdbsum/4gu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
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===Crystal structure of the T1L reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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{{ABSTRACT_PUBMED_23236285}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4gu4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_lang Mammalian orthoreovirus 1 lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU4 OCA].
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[[Category: Mammalian orthoreovirus 1 Lang]]
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[[Category: Mammalian orthoreovirus 1 lang]]
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[[Category: Reiss K]]
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[[Category: Reiss, K.]]
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[[Category: Stehle T]]
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[[Category: Stehle, T.]]
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[[Category: 3-sialyllactose junctional adhesion molecule some]]
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[[Category: Beta-barrel]]
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[[Category: Beta-spiral repeat]]
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[[Category: Gm2 glycan alpha-2]]
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[[Category: Greek key motif]]
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[[Category: Triple beta-spiral]]
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[[Category: Viral attachment protein]]
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[[Category: Viral capsid]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of the T1L reovirus attachment protein sigma1 in complex with alpha-2,3-sialyllactose

PDB ID 4gu4

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