4gxx

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[[Image:4gxx.png|left|200px]]
 
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{{STRUCTURE_4gxx| PDB=4gxx | SCENE= }}
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==Crystal structure of the "avianized" 1918 influenza virus hemagglutinin==
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<StructureSection load='4gxx' size='340' side='right'caption='[[4gxx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gxx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Brevig_Mission/1/1918(H1N1)) Influenza A virus (A/Brevig Mission/1/1918(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GXX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.799&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gxx OCA], [https://pdbe.org/4gxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gxx RCSB], [https://www.ebi.ac.uk/pdbsum/4gxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gxx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_I18A0 HEMA_I18A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
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===Crystal structure of the "avianized" 1918 influenza virus hemagglutinin===
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==See Also==
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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{{ABSTRACT_PUBMED_23236279}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4gxx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/brevig_mission/1/1918(h1n1)) Influenza a virus (a/brevig mission/1/1918(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GXX OCA].
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[[Category: Ekiert DC]]
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[[Category: Ekiert, D C.]]
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[[Category: Wilson IA]]
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[[Category: Wilson, I A.]]
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[[Category: Viral fusion protein]]
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[[Category: Viral protein]]
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[[Category: Virus attachment and entry]]
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Current revision

Crystal structure of the "avianized" 1918 influenza virus hemagglutinin

PDB ID 4gxx

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