4gu3
From Proteopedia
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| - | [[Image:4gu3.png|left|200px]] | ||
| - | + | ==Crystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycan== | |
| + | <StructureSection load='4gu3' size='340' side='right'caption='[[4gu3]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gu3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GU3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gu3 OCA], [https://pdbe.org/4gu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gu3 RCSB], [https://www.ebi.ac.uk/pdbsum/4gu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gu3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[ | + | [[Category: Mammalian orthoreovirus 1 Lang]] |
| - | [[Category: Mammalian orthoreovirus 1 | + | [[Category: Reiss K]] |
| - | [[Category: Reiss | + | [[Category: Stehle T]] |
| - | [[Category: Stehle | + | |
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Current revision
Crystal structure of the T1L reovirus attachment protein sigma1 in complex with the GM2 glycan
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