3w2y

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'''Unreleased structure'''
 
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The entry 3w2y is ON HOLD until Paper Publication
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==Crystal structure of DNA uridine endonuclease Mth212 mutant W205S==
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<StructureSection load='3w2y' size='340' side='right'caption='[[3w2y]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Tabata, N., Shida, T., Arai, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w2y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W2Y FirstGlance]. <br>
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Description: Crystal structure of DNA uridine endonuclease Mth212 mutant W205S
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2y OCA], [https://pdbe.org/3w2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w2y RCSB], [https://www.ebi.ac.uk/pdbsum/3w2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UREND_METTH UREND_METTH] Involved in DNA uracil repair (PubMed:17012282, PubMed:19240141, PubMed:20129830). Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide (PubMed:17012282, PubMed:19240141, PubMed:20129830). In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease (PubMed:15725624, PubMed:17012282). Strongly binds to double-stranded DNA (PubMed:15725624).<ref>PMID:15725624</ref> <ref>PMID:17012282</ref> <ref>PMID:19240141</ref> <ref>PMID:20129830</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
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[[Category: Arai R]]
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[[Category: Shida T]]
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[[Category: Tabata N]]

Current revision

Crystal structure of DNA uridine endonuclease Mth212 mutant W205S

PDB ID 3w2y

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