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4iip
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4iip is ON HOLD Authors: Tascon, I., Chen, Y, Neunuebel, M. R., Rojas, A. L., Machner, M. P., Hierro, A. Description: Legionella pneumophila effect...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Legionella pneumophila effector== | |
| - | + | <StructureSection load='4iip' size='340' side='right'caption='[[4iip]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4iip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IIP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iip OCA], [https://pdbe.org/4iip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iip RCSB], [https://www.ebi.ac.uk/pdbsum/4iip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iip ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIDD_LEGPH SIDD_LEGPH] Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De-AMPylation of RAB1B cannot take place when LidA is bound to RAB1B.<ref>PMID:21734656</ref> <ref>PMID:21680813</ref> <ref>PMID:22228731</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Hierro A]] | ||
| + | [[Category: Machner MP]] | ||
| + | [[Category: Neunuebel MR]] | ||
| + | [[Category: Rojas AL]] | ||
| + | [[Category: Tascon I]] | ||
Current revision
Legionella pneumophila effector
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