4ijd
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4ijd is ON HOLD Authors: DONG, A., DOMBROVSKI,L., LI, Y., TEMPEL, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of methyltransferase domain of human PR domain-containing protein 9== | |
| + | <StructureSection load='4ijd' size='340' side='right'caption='[[4ijd]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ijd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijd OCA], [https://pdbe.org/4ijd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijd RCSB], [https://www.ebi.ac.uk/pdbsum/4ijd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRDM9_HUMAN PRDM9_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Brown PJ]] | ||
| + | [[Category: Dombrovski L]] | ||
| + | [[Category: Dong A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Wu H]] | ||
Current revision
Crystal structure of methyltransferase domain of human PR domain-containing protein 9
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Brown PJ | Dombrovski L | Dong A | Edwards AM | Li Y | Tempel W | Wu H
