2m1r

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[[Image:2m1r.jpg|left|200px]]
 
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{{STRUCTURE_2m1r| PDB=2m1r | SCENE= }}
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==PHD domain of ING4 N214D mutant==
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<StructureSection load='2m1r' size='340' side='right'caption='[[2m1r]]' scene=''>
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===PHD domain of ING4 N214D mutant===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2m1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1R FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20705953}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1r OCA], [https://pdbe.org/2m1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1r RCSB], [https://www.ebi.ac.uk/pdbsum/2m1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1r ProSAT]</span></td></tr>
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[[2m1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1R OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ING4_HUMAN ING4_HUMAN] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).<ref>PMID:12750254</ref> <ref>PMID:15251430</ref> <ref>PMID:15029197</ref> <ref>PMID:15528276</ref> <ref>PMID:15897452</ref> <ref>PMID:16387653</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blanco, F J.]]
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[[Category: Large Structures]]
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[[Category: Gene regulation]]
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[[Category: Blanco FJ]]
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[[Category: Ing4]]
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[[Category: Phd]]
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[[Category: Transcription]]
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Current revision

PHD domain of ING4 N214D mutant

PDB ID 2m1r

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OCA

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