2lo6

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[[Image:2lo6.jpg|left|200px]]
 
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{{STRUCTURE_2lo6| PDB=2lo6 | SCENE= }}
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==Structure of Nrd1 CID bound to phosphorylated RNAP II CTD==
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<StructureSection load='2lo6' size='340' side='right'caption='[[2lo6]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lo6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LO6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo6 OCA], [https://pdbe.org/2lo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lo6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lo6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NRD1_YEAST NRD1_YEAST] Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Recruitment of appropriate RNA processing factors to the site of transcription is controlled by post-translational modifications of the C-terminal domain (CTD) of RNA polymerase II (RNAP II). Here, we report the solution structure of the Ser5 phosphorylated (pSer5) CTD bound to Nrd1. The structure reveals a direct recognition of pSer5 by Nrd1 that requires the cis conformation of the upstream pSer5-Pro6 peptidyl-prolyl bond of the CTD. Mutations at the complex interface diminish binding affinity and impair processing or degradation of noncoding RNAs. These findings underpin the interplay between covalent and noncovalent changes in the CTD structure that constitute the CTD code.
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===Structure of Nrd1 CID bound to phosphorylated RNAP II CTD===
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Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1.,Kubicek K, Cerna H, Holub P, Pasulka J, Hrossova D, Loehr F, Hofr C, Vanacova S, Stefl R Genes Dev. 2012 Sep 1;26(17):1891-6. doi: 10.1101/gad.192781.112. Epub 2012 Aug, 14. PMID:22892239<ref>PMID:22892239</ref>
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{{ABSTRACT_PUBMED_22892239}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2lo6" style="background-color:#fffaf0;"></div>
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[[2lo6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO6 OCA].
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== References ==
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[[Category: DNA-directed RNA polymerase]]
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<references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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__TOC__
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[[Category: Cerna, H.]]
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</StructureSection>
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[[Category: Hofr, C.]]
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[[Category: Large Structures]]
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[[Category: Holub, P.]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Hrossova, D.]]
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[[Category: Cerna H]]
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[[Category: Kubicek, K.]]
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[[Category: Hofr C]]
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[[Category: Loehr, F.]]
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[[Category: Holub P]]
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[[Category: Pasulka, J.]]
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[[Category: Hrossova D]]
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[[Category: Stefl, R.]]
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[[Category: Kubicek K]]
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[[Category: Vanacova, S.]]
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[[Category: Loehr F]]
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[[Category: Carboxy-terminal domain]]
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[[Category: Pasulka J]]
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[[Category: Cid]]
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[[Category: Stefl R]]
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[[Category: Cis-trans isomerization of proline]]
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[[Category: Vanacova S]]
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[[Category: Ctd]]
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[[Category: Ctd-interacting domain]]
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[[Category: Ess1 isomerase]]
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[[Category: Peptide binding protein]]
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[[Category: Rna-processing]]
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[[Category: Transciption termination]]
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[[Category: Transcription]]
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Current revision

Structure of Nrd1 CID bound to phosphorylated RNAP II CTD

PDB ID 2lo6

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