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1qtu
From Proteopedia
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| - | [[Image:1qtu.png|left|200px]] | ||
| - | + | ==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1== | |
| - | + | <StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [https://pdbe.org/1qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [https://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1qtu]] is a 1 chain structure with sequence from [ | + | == Disease == |
| - | + | [https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia. | |
| - | == | + | == Function == |
| - | < | + | [https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref> |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtu_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtu ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Guignard | + | [[Category: Large Structures]] |
| - | [[Category: Lhoste | + | [[Category: Guignard L]] |
| - | [[Category: Mispelter | + | [[Category: Lhoste J-M]] |
| - | [[Category: Padilla | + | [[Category: Mispelter J]] |
| - | [[Category: Roumestand | + | [[Category: Padilla A]] |
| - | [[Category: Stern | + | [[Category: Roumestand C]] |
| - | [[Category: Yang | + | [[Category: Stern M-H]] |
| - | + | [[Category: Yang Y-S]] | |
| - | + | ||
Current revision
SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1
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