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1qx6

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[[Image:1qx6.png|left|200px]]
 
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{{STRUCTURE_1qx6| PDB=1qx6 | SCENE= }}
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==Crystal structure of Sortase B complexed with E-64==
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<StructureSection load='1qx6' size='340' side='right'caption='[[1qx6]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Crystal structure of Sortase B complexed with E-64===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QX6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14725770}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E64:N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE'>E64</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qx6 OCA], [https://pdbe.org/1qx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qx6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qx6 ProSAT]</span></td></tr>
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[[1qx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QX6 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SRTB_STAA8 SRTB_STAA8] Transpeptidase that anchors surface proteins to the cell wall (PubMed:11830639, PubMed:15718231, PubMed:24519933) (Probable). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable) (PubMed:24519933). This sortase recognizes an Asn-Pro-Gln-Thr-Asn (NPQTN) motif in IsdC, which is cleaved by the sortase between the threonine and aspargine residues; may only have 1 substrate in this bacterium (Probable). May be dedicated to the process of iron acquisition during bacterial infection (Probable).<ref>PMID:11830639</ref> <ref>PMID:15718231</ref> <ref>PMID:24519933</ref> <ref>PMID:11830639</ref> <ref>PMID:15718231</ref> <ref>PMID:29690584</ref>
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<ref group="xtra">PMID:014725770</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qx/1qx6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qx6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Mazmanian, S K.]]
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[[Category: Mazmanian SK]]
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[[Category: Narayana, S V.]]
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[[Category: Narayana SV]]
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[[Category: Schneewind, O.]]
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[[Category: Schneewind O]]
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[[Category: Zong, Y.]]
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[[Category: Zong Y]]
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[[Category: Cysteine protease]]
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[[Category: E-64]]
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[[Category: Hydrolase]]
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[[Category: Sortase]]
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[[Category: Transpeptidase]]
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Current revision

Crystal structure of Sortase B complexed with E-64

PDB ID 1qx6

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