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1qub

From Proteopedia

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[[Image:1qub.png|left|200px]]
 
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{{STRUCTURE_1qub| PDB=1qub | SCENE= }}
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==CRYSTAL STRUCTURE OF THE GLYCOSYLATED FIVE-DOMAIN HUMAN BETA2-GLYCOPROTEIN I PURIFIED FROM BLOOD PLASMA==
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<StructureSection load='1qub' size='340' side='right'caption='[[1qub]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE GLYCOSYLATED FIVE-DOMAIN HUMAN BETA2-GLYCOPROTEIN I PURIFIED FROM BLOOD PLASMA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QUB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_10508150}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qub OCA], [https://pdbe.org/1qub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qub RCSB], [https://www.ebi.ac.uk/pdbsum/1qub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qub ProSAT]</span></td></tr>
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[[1qub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QUB OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/APOH_HUMAN APOH_HUMAN] Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
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<ref group="xtra">PMID:010508150</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/1qub_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qub ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bouma, B.]]
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[[Category: Large Structures]]
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[[Category: Derksen, R H.W M.]]
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[[Category: Bouma B]]
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[[Category: Elsen, J M.H van den.]]
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[[Category: Derksen RHWM]]
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[[Category: Groot, Ph G.de.]]
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[[Category: Gros P]]
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[[Category: Gros, P.]]
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[[Category: Kroon J]]
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[[Category: Kroon, J.]]
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[[Category: Ravelli RBG]]
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[[Category: Ravelli, R B.G.]]
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[[Category: Schouten A]]
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[[Category: Schouten, A.]]
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[[Category: Simmelink MJA]]
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[[Category: Simmelink, M J.A.]]
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[[Category: De Groot PG]]
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[[Category: Complement control protein]]
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[[Category: Van den Elsen JMH]]
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[[Category: Membrane adhesion]]
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[[Category: Multi-domain]]
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[[Category: N-glycosylation]]
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[[Category: Short consensus repeat]]
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[[Category: Sushi]]
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Current revision

CRYSTAL STRUCTURE OF THE GLYCOSYLATED FIVE-DOMAIN HUMAN BETA2-GLYCOPROTEIN I PURIFIED FROM BLOOD PLASMA

PDB ID 1qub

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