1q14

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[[Image:1q14.png|left|200px]]
 
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{{STRUCTURE_1q14| PDB=1q14 | SCENE= }}
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==Structure and autoregulation of the yeast Hst2 homolog of Sir2==
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<StructureSection load='1q14' size='340' side='right'caption='[[1q14]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Structure and autoregulation of the yeast Hst2 homolog of Sir2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q14 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14502267}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q14 OCA], [https://pdbe.org/1q14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q14 RCSB], [https://www.ebi.ac.uk/pdbsum/1q14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q14 ProSAT]</span></td></tr>
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[[1q14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q14 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/HST2_YEAST HST2_YEAST] NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export.<ref>PMID:10811920</ref> <ref>PMID:11106374</ref> <ref>PMID:11226170</ref> <ref>PMID:15274642</ref> <ref>PMID:17110954</ref>
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<ref group="xtra">PMID:014502267</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q1/1q14_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q14 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Chai, X.]]
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[[Category: Chai X]]
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[[Category: Clements, A.]]
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[[Category: Clements A]]
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[[Category: Marmorstein, R.]]
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[[Category: Marmorstein R]]
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[[Category: Zhao, K.]]
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[[Category: Zhao K]]
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[[Category: Histone deacetylase]]
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[[Category: Hydrolase]]
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Current revision

Structure and autoregulation of the yeast Hst2 homolog of Sir2

PDB ID 1q14

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