1qm9

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[[Image:1qm9.png|left|200px]]
 
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{{STRUCTURE_1qm9| PDB=1qm9 | SCENE= }}
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==NMR, REPRESENTATIVE STRUCTURE==
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<StructureSection load='1qm9' size='340' side='right'caption='[[1qm9]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QM9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qm9 OCA], [https://pdbe.org/1qm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qm9 RCSB], [https://www.ebi.ac.uk/pdbsum/1qm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qm9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/1qm9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qm9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Polypyrimidine tract binding protein (PTB), an RNA binding protein containing four RNA recognition motifs (RRMs), is involved in both pre-mRNA splicing and translation initiation directed by picornaviral internal ribosome entry sites. Sequence comparisons previously indicated that PTB is a non-canonical RRM protein. The solution structure of a PTB fragment containing RRMs 3 and 4 shows that the protein consists of two domains connected by a long, flexible linker. The two domains tumble independently in solution, having no fixed relative orientation. In addition to the betaalphabetabetaalphabeta topology, which is characteristic of RRM domains, the C-terminal extension of PTB RRM-3 incorporates an unanticipated fifth beta-strand, which extends the RNA binding surface. The long, disordered polypeptide connecting beta4 and beta5 in RRM-3 is poised above the RNA binding surface and is likely to contribute to RNA recognition. Mutational analyses show that both RRM-3 and RRM-4 contribute to RNA binding specificity and that, despite its unusual sequence, PTB binds RNA in a manner akin to that of other RRM proteins.
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===NMR, REPRESENTATIVE STRUCTURE===
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Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.,Conte MR, Grune T, Ghuman J, Kelly G, Ladas A, Matthews S, Curry S EMBO J. 2000 Jun 15;19(12):3132-41. PMID:10856256<ref>PMID:10856256</ref>
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{{ABSTRACT_PUBMED_10856256}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1qm9" style="background-color:#fffaf0;"></div>
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[[1qm9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QM9 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010856256</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Conte, M R.]]
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[[Category: Large Structures]]
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[[Category: Curry, S.]]
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[[Category: Conte MR]]
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[[Category: Grune, T.]]
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[[Category: Curry S]]
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[[Category: Matthews, S.]]
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[[Category: Grune T]]
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[[Category: Polypyrimidine tract binding protein]]
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[[Category: Matthews S]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna]]
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[[Category: Rnp]]
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[[Category: Spicing]]
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[[Category: Translation]]
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Current revision

NMR, REPRESENTATIVE STRUCTURE

PDB ID 1qm9

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