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1q74

From Proteopedia

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[[Image:1q74.png|left|200px]]
 
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{{STRUCTURE_1q74| PDB=1q74 | SCENE= }}
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==The Crystal Structure of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)==
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<StructureSection load='1q74' size='340' side='right'caption='[[1q74]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===The Crystal Structure of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q74]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q74 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12958317}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q74 OCA], [https://pdbe.org/1q74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q74 RCSB], [https://www.ebi.ac.uk/pdbsum/1q74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q74 ProSAT], [https://www.topsan.org/Proteins/TBSGC/1q74 TOPSAN]</span></td></tr>
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[[1q74]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q74 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/MSHB_MYCTU MSHB_MYCTU] Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol (MSH) biosynthesis pathway. Shows some amidase activity toward S-conjugates of mycothiol.<ref>PMID:11092856</ref>
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<ref group="xtra">PMID:012958317</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/1q74_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q74 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Arad, D.]]
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[[Category: Arad D]]
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[[Category: Av-Gay, Y.]]
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[[Category: Av-Gay Y]]
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[[Category: Cherney, M M.]]
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[[Category: Cherney MM]]
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[[Category: Fahey, R C.]]
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[[Category: Fahey RC]]
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[[Category: Garen, C.]]
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[[Category: Garen C]]
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[[Category: James, M N.]]
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[[Category: James MN]]
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[[Category: Maynes, J T.]]
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[[Category: Maynes JT]]
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[[Category: Newton, G.]]
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[[Category: Newton G]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Hydrolase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Rossmann fold]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Zinc aminohydrolase]]
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Current revision

The Crystal Structure of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)

PDB ID 1q74

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