1rxq

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[[Image:1rxq.png|left|200px]]
 
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{{STRUCTURE_1rxq| PDB=1rxq | SCENE= }}
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==YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology==
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<StructureSection load='1rxq' size='340' side='right'caption='[[1rxq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rxq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>, <scene name='pdbligand=THR:THREONINE'>THR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxq OCA], [https://pdbe.org/1rxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxq RCSB], [https://www.ebi.ac.uk/pdbsum/1rxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxq ProSAT], [https://www.topsan.org/Proteins/MCSG/1rxq TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YFIT_BACSU YFIT_BACSU] Possible metal-dependent hydrolase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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YfiT, a 19-kDa polypeptide from Bacillus subtilis, belongs to a small sequence family with members predominantly from Gram positive bacteria. We have determined the crystal structure of YfiT in complex with Ni(2+) to a resolution of 1.7 A. YfiT exists as a dimer and binds Ni(2+) in a 1:1 stoichiometry. The protein has an unusual four-helix bundle topology and coordinates Ni(2+) in an octahedral geometry with three conserved histidines and three waters. Although there is no similarity in their overall structures, the coordination geometry of the metal and the residues that constitute the putative active site in YfiT are similar to those of metalloproteases such as thermolysin. Our structural analyses suggest that YfiT might function as a metal-dependent hydrolase.
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===YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology===
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YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology.,Rajan SS, Yang X, Shuvalova L, Collart F, Anderson WF Biochemistry. 2004 Dec 14;43(49):15472-9. PMID:15581359<ref>PMID:15581359</ref>
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{{ABSTRACT_PUBMED_15581359}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1rxq" style="background-color:#fffaf0;"></div>
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[[1rxq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXQ OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015581359</ref><references group="xtra"/>
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Anderson, W F.]]
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[[Category: Large Structures]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Anderson WF]]
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[[Category: Rajan, S S.]]
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[[Category: Rajan SS]]
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[[Category: Yang, X.]]
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[[Category: Yang X]]
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[[Category: Helix-bundle]]
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[[Category: Hydrolase]]
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[[Category: Mcsg]]
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[[Category: Metal-binding protein]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Nickel-binding]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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Current revision

YfiT from Bacillus subtilis is a probable metal-dependent hydrolase with an unusual four-helix bundle topology

PDB ID 1rxq

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