1rsz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1rsz" [edit=sysop:move=sysop])
Current revision (06:07, 23 August 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1rsz.png|left|200px]]
 
-
{{STRUCTURE_1rsz| PDB=1rsz | SCENE= }}
+
==Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate==
 +
<StructureSection load='1rsz' size='340' side='right'caption='[[1rsz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1rsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RSZ FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIH:3-HYDROXY-4-HYDROXYMETHYL-1-(4-OXO-4,4A,5,7A-TETRAHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YLMETHYL)-PYRROLIDINIUM'>DIH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsz OCA], [https://pdbe.org/1rsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rsz RCSB], [https://www.ebi.ac.uk/pdbsum/1rsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rsz ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rs/1rsz_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rsz ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate===
+
==See Also==
-
 
+
*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
[[1rsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RSZ OCA].
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Purine-nucleoside phosphorylase]]
+
[[Category: Large Structures]]
-
[[Category: Almo, S C.]]
+
[[Category: Almo SC]]
-
[[Category: Furneaux, R H.]]
+
[[Category: Furneaux RH]]
-
[[Category: Lewandowicz, A.]]
+
[[Category: Lewandowicz A]]
-
[[Category: Schramm, V L.]]
+
[[Category: Schramm VL]]
-
[[Category: Shi, W.]]
+
[[Category: Shi W]]
-
[[Category: Tyler, P C.]]
+
[[Category: Tyler PC]]
-
[[Category: Pnp]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transition-state analogue]]
+

Current revision

Structure of human purine nucleoside phosphorylase in complex with DADMe-Immucillin-H and sulfate

PDB ID 1rsz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rsz"
Personal tools