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1sqt

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[[Image:1sqt.png|left|200px]]
 
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{{STRUCTURE_1sqt| PDB=1sqt | SCENE= }}
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==Substituted 2-Naphthamidine Inhibitors of Urokinase==
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<StructureSection load='1sqt' size='340' side='right'caption='[[1sqt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqt OCA], [https://pdbe.org/1sqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqt RCSB], [https://www.ebi.ac.uk/pdbsum/1sqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sqt ConSurf].
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<div style="clear:both"></div>
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===Substituted 2-Naphthamidine Inhibitors of Urokinase===
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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{{ABSTRACT_PUBMED_15149645}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1sqt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQT OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015149645</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: U-plasminogen activator]]
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[[Category: Large Structures]]
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[[Category: Geyer, A.]]
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[[Category: Geyer A]]
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[[Category: Giranda, V L.]]
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[[Category: Giranda VL]]
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[[Category: Klinghofer, V.]]
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[[Category: Klinghofer V]]
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[[Category: Mantei, R.]]
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[[Category: Mantei R]]
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[[Category: McClellan, W J.]]
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[[Category: McClellan WJ]]
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[[Category: Nienaber, V.]]
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[[Category: Nienaber V]]
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[[Category: Rockway, T W.]]
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[[Category: Rockway TW]]
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[[Category: Stewart, K.]]
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[[Category: Stewart K]]
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[[Category: Weitzberg, M.]]
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[[Category: Weitzberg M]]
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[[Category: Wendt, M D.]]
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[[Category: Wendt MD]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Kringle]]
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[[Category: Plasminogen activation]]
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[[Category: Serine protease]]
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Current revision

Substituted 2-Naphthamidine Inhibitors of Urokinase

PDB ID 1sqt

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