1sfp

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[[Image:1sfp.png|left|200px]]
 
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{{STRUCTURE_1sfp| PDB=1sfp | SCENE= }}
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==CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY==
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<StructureSection load='1sfp' size='340' side='right'caption='[[1sfp]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SFP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sfp OCA], [https://pdbe.org/1sfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sfp RCSB], [https://www.ebi.ac.uk/pdbsum/1sfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sfp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPAD1_BOVIN SPAD1_BOVIN] Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sf/1sfp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sfp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins involved in sperm-egg binding and display a single CUB domain architecture. We report the crystal structures of porcine seminal plasma PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine aSFP at 2.4 A and 1.9 A resolution respectively.
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===CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY===
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The crystal structures of two spermadhesins reveal the CUB domain fold.,Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:9334740<ref>PMID:9334740</ref>
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{{ABSTRACT_PUBMED_9334740}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1sfp" style="background-color:#fffaf0;"></div>
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[[1sfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFP OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009334740</ref><ref group="xtra">PMID:011880627</ref><ref group="xtra">PMID:019113835</ref><references group="xtra"/>
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Calvete, J J.]]
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[[Category: Large Structures]]
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[[Category: Carvalho, A L.]]
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[[Category: Calvete JJ]]
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[[Category: Dias, J M.]]
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[[Category: Carvalho AL]]
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[[Category: Kolln, I.]]
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[[Category: Dias JM]]
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[[Category: Romao, M J.]]
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[[Category: Kolln I]]
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[[Category: Romero, A.]]
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[[Category: Romao MJ]]
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[[Category: Sanz, L.]]
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[[Category: Romero A]]
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[[Category: Topfer-Petersen, E.]]
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[[Category: Sanz L]]
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[[Category: Varela, P F.]]
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[[Category: Topfer-Petersen E]]
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[[Category: Acidic seminal fluid protein]]
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[[Category: Varela PF]]
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[[Category: Asfp]]
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[[Category: Bovine seminal plasma protein]]
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[[Category: Cub domain]]
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[[Category: Growth factor]]
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[[Category: Spermadhesin]]
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[[Category: X-ray crystal structure]]
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Current revision

CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY

PDB ID 1sfp

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