1sji

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[[Image:1sji.png|left|200px]]
 
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{{STRUCTURE_1sji| PDB=1sji | SCENE= }}
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==Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization==
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<StructureSection load='1sji' size='340' side='right'caption='[[1sji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJI FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14871888}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sji OCA], [https://pdbe.org/1sji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sji RCSB], [https://www.ebi.ac.uk/pdbsum/1sji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sji ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1sji]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJI OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/CASQ2_CANLF CASQ2_CANLF] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.<ref>PMID:14871888</ref> <ref>PMID:20302875</ref> <ref>PMID:3427023</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:014871888</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sji_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sji ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Dunker, A K.]]
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[[Category: Large Structures]]
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[[Category: Fields, K.]]
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[[Category: Dunker AK]]
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[[Category: Kang, C H.]]
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[[Category: Fields K]]
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[[Category: Kim, E J.]]
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[[Category: Kang CH]]
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[[Category: Park, H J.]]
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[[Category: Kim EJ]]
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[[Category: Park, I Y.]]
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[[Category: Park HJ]]
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[[Category: Youn, B.]]
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[[Category: Park IY]]
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[[Category: Calcium-binding]]
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[[Category: Youn B]]
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[[Category: Calsequestrin]]
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[[Category: Glycoprotein]]
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[[Category: Metal binding protein]]
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[[Category: Muscle protein]]
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Current revision

Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization

PDB ID 1sji

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