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1r17
From Proteopedia
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| - | [[Image:1r17.png|left|200px]] | ||
| - | + | ==Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)== | |
| + | <StructureSection load='1r17' size='340' side='right'caption='[[1r17]], [[Resolution|resolution]] 1.86Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1r17]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R17 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r17 OCA], [https://pdbe.org/1r17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r17 RCSB], [https://www.ebi.ac.uk/pdbsum/1r17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r17 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SDRG_STAEP SDRG_STAEP] Binds to the N-terminus of the B beta-chain of human fibrinogen and thereby interferes with thrombin cleavage and release of fibrinopeptide B, thus interfering with fibrin clot formation. This may hinder host defense against microbial infections.<ref>PMID:11371571</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r17_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r17 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Fibrinogen binding protein|Fibrinogen binding protein]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[ | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
| - | == | + | |
| - | < | + | |
[[Category: Staphylococcus epidermidis]] | [[Category: Staphylococcus epidermidis]] | ||
| - | [[Category: Bowden | + | [[Category: Bowden MG]] |
| - | [[Category: Choe | + | [[Category: Choe D]] |
| - | [[Category: Davis | + | [[Category: Davis S]] |
| - | [[Category: Gurusiddappa | + | [[Category: Gurusiddappa S]] |
| - | [[Category: Hook | + | [[Category: Hook M]] |
| - | [[Category: Moore | + | [[Category: Moore D]] |
| - | [[Category: Narayana | + | [[Category: Narayana SVL]] |
| - | [[Category: Ponnuraj | + | [[Category: Ponnuraj K]] |
| - | [[Category: Xu | + | [[Category: Xu Y]] |
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Current revision
Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)
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Categories: Large Structures | Staphylococcus epidermidis | Bowden MG | Choe D | Davis S | Gurusiddappa S | Hook M | Moore D | Narayana SVL | Ponnuraj K | Xu Y
