1s3l

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[[Image:1s3l.png|left|200px]]
 
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{{STRUCTURE_1s3l| PDB=1s3l | SCENE= }}
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==Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase==
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<StructureSection load='1s3l' size='340' side='right'caption='[[1s3l]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S3L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15128743}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s3l OCA], [https://pdbe.org/1s3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s3l RCSB], [https://www.ebi.ac.uk/pdbsum/1s3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s3l ProSAT], [https://www.topsan.org/Proteins/BSGC/1s3l TOPSAN]</span></td></tr>
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[[1s3l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3L OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/P936_METJA P936_METJA] Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p-nitrophenylphosphorylcholine (pNPPC). No catalytic activity was found toward cAMP or cGMP, nucleotides or phospholipase substrates such as phosphatidylcholine. The physiological substrate is unknown.
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<ref group="xtra">PMID:015128743</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s3/1s3l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s3l ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Busso D]]
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[[Category: Busso, D.]]
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[[Category: Chen S]]
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[[Category: Chen, S.]]
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[[Category: Jancrick J]]
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[[Category: Jancrick, J.]]
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[[Category: Kim R]]
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[[Category: Kim, R.]]
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[[Category: Kim S-H]]
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[[Category: Kim, S H.]]
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[[Category: Kuznetsova E]]
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[[Category: Kuznetsova, E.]]
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[[Category: Proudfoot M]]
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[[Category: Proudfoot, M.]]
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[[Category: Yakunin AF]]
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[[Category: Yakunin, A F.]]
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[[Category: Berkeley structural genomics center]]
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[[Category: Bsgc structure funded by nih]]
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[[Category: Nuclease]]
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[[Category: Phosphodiesterase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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Current revision

Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase

PDB ID 1s3l

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