1r0n

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[[Image:1r0n.png|left|200px]]
 
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{{STRUCTURE_1r0n| PDB=1r0n | SCENE= }}
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==Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex==
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<StructureSection load='1r0n' size='340' side='right'caption='[[1r0n]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r0n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0n OCA], [https://pdbe.org/1r0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0n RCSB], [https://www.ebi.ac.uk/pdbsum/1r0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RXRA_HUMAN RXRA_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.<ref>PMID:10195690</ref> <ref>PMID:11162439</ref> <ref>PMID:11915042</ref> <ref>PMID:20215566</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/1r0n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r0n ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex===
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==See Also==
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*[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]]
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{{ABSTRACT_PUBMED_14592980}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1r0n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0N OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014592980</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Devarakonda, S.]]
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[[Category: Large Structures]]
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[[Category: Harp, J M.]]
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[[Category: Devarakonda S]]
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[[Category: Kim, Y.]]
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[[Category: Harp JM]]
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[[Category: Ozyhar, A.]]
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[[Category: Kim Y]]
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[[Category: Rastinejad, F.]]
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[[Category: Ozyhar A]]
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[[Category: Dna binding domain]]
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[[Category: Rastinejad F]]
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[[Category: Ecdysone receptor]]
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[[Category: Nuclear receptor]]
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[[Category: Rxr]]
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[[Category: Transcription-dna complex]]
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[[Category: Ultraspiracle]]
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Current revision

Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex

PDB ID 1r0n

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