1rrp

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[[Image:1rrp.png|left|200px]]
 
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{{STRUCTURE_1rrp| PDB=1rrp | SCENE= }}
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==STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX==
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<StructureSection load='1rrp' size='340' side='right'caption='[[1rrp]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rrp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RRP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rrp OCA], [https://pdbe.org/1rrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rrp RCSB], [https://www.ebi.ac.uk/pdbsum/1rrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rrp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rr/1rrp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rrp ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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{{ABSTRACT_PUBMED_10078529}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1rrp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RRP OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:010078529</ref><ref group="xtra">PMID:017009862</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kuhlmann, J.]]
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[[Category: Large Structures]]
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[[Category: Nishimoto, T.]]
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[[Category: Kuhlmann J]]
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[[Category: Nowak, C.]]
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[[Category: Nishimoto T]]
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[[Category: Vetter, I R.]]
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[[Category: Nowak C]]
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[[Category: Wittinghofer, A.]]
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[[Category: Vetter IR]]
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[[Category: Nuclear transport]]
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[[Category: Wittinghofer A]]
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[[Category: Small gtpase]]
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Current revision

STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX

PDB ID 1rrp

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