1rj8

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[[Image:1rj8.png|left|200px]]
 
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{{STRUCTURE_1rj8| PDB=1rj8 | SCENE= }}
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==The crystal structure of TNF family member EDA-A2==
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<StructureSection load='1rj8' size='340' side='right'caption='[[1rj8]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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===The crystal structure of TNF family member EDA-A2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rj8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RJ8 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14656435}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rj8 OCA], [https://pdbe.org/1rj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rj8 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1rj8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJ8 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/EDA_HUMAN EDA_HUMAN] Defects in EDA are the cause of ectodermal dysplasia 1, hypohidrotic, X-linked (XHED) [MIM:[https://omim.org/entry/305100 305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. XHED is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. XHED is the most common form of over 150 clinically distinct ectodermal dysplasias.<ref>PMID:8696334</ref> <ref>PMID:9683615</ref> <ref>PMID:9736768</ref> <ref>PMID:11309369</ref> <ref>PMID:11416205</ref> <ref>PMID:9630076</ref> <ref>PMID:9507389</ref> <ref>PMID:10469321</ref> <ref>PMID:10951256</ref> <ref>PMID:11343303</ref> <ref>PMID:11378824</ref> <ref>PMID:11295832</ref> <ref>PMID:11279189</ref> <ref>PMID:12225002</ref> <ref>PMID:12932274</ref> <ref>PMID:17256800</ref> <ref>PMID:18231121</ref> <ref>PMID:19438931</ref> <ref>PMID:19127222</ref> <ref>PMID:20486090</ref> <ref>PMID:20979233</ref> <ref>PMID:22008666</ref> <ref>PMID:22350046</ref> Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:[https://omim.org/entry/313500 313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).<ref>PMID:16583127</ref> <ref>PMID:18657636</ref>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:014656435</ref><ref group="xtra">PMID:018160966</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/EDA_HUMAN EDA_HUMAN] Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/1rj8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rj8 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ackerly, H.]]
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[[Category: Large Structures]]
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[[Category: Compaan, D M.]]
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[[Category: Ackerly H]]
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[[Category: Dixit, V M.]]
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[[Category: Compaan DM]]
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[[Category: Hymowitz, S G.]]
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[[Category: Dixit VM]]
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[[Category: Starovasnik, M A.]]
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[[Category: Hymowitz SG]]
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[[Category: Vos, A M.de.]]
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[[Category: Starovasnik MA]]
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[[Category: Yan, M.]]
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[[Category: Yan M]]
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[[Category: Hormone-growth factor complex]]
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[[Category: De Vos AM]]
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[[Category: Jelly roll]]
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[[Category: Splice variant]]
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[[Category: Tnf domain]]
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[[Category: Trimer]]
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Current revision

The crystal structure of TNF family member EDA-A2

PDB ID 1rj8

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