1sfu
From Proteopedia
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| - | [[Image:1sfu.png|left|200px]] | ||
| - | + | ==Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA== | |
| + | <StructureSection load='1sfu' size='340' side='right'caption='[[1sfu]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1sfu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yaba-like_disease_virus Yaba-like disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SFU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sfu OCA], [https://pdbe.org/1sfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sfu RCSB], [https://www.ebi.ac.uk/pdbsum/1sfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sfu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/E3_YLDV E3_YLDV] RNA-binding protein that plays a role in the inhibition of multiple cellular antiviral responses activated by double-stranded RNA (dsRNA), such as inhibition of PKR activation, necroptosis, and IFN-mediated antiviral activities (By similarity). Recognizes and binds Z-RNA structures via its Z-binding domain and dsRNA via its DRBM domain: RNA-binding activity is required to escape host ZBP1-dependent necroptosis (By similarity). Mechanistically, the Z-binding domain binds Z-RNAs that are produced during Yaba-like disease virus infection, thereby competing with Z-RNA detection by host ZBP1, suppressing ZBP1-dependent necroptosis (By similarity).[UniProtKB:P21605] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sf/1sfu_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sfu ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Z-DNA|Z-DNA]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[ | + | |
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| - | < | + | |
[[Category: Yaba-like disease virus]] | [[Category: Yaba-like disease virus]] | ||
| - | [[Category: Ha | + | [[Category: Ha SC]] |
| - | [[Category: Kim | + | [[Category: Kim KK]] |
| - | [[Category: Kim | + | [[Category: Kim YG]] |
| - | [[Category: Lowenhaupt | + | [[Category: Lowenhaupt K]] |
| - | + | [[Category: Rich A]] | |
| - | [[Category: Rich | + | [[Category: Van Quyen D]] |
| - | [[Category: | + | [[Category: Wu CA]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of the viral Zalpha domain bound to left-handed Z-DNA
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Categories: Large Structures | Yaba-like disease virus | Ha SC | Kim KK | Kim YG | Lowenhaupt K | Rich A | Van Quyen D | Wu CA
