1r8n

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[[Image:1r8n.png|left|200px]]
 
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{{STRUCTURE_1r8n| PDB=1r8n | SCENE= }}
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==The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia==
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<StructureSection load='1r8n' size='340' side='right'caption='[[1r8n]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r8n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Delonix_regia Delonix regia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8n OCA], [https://pdbe.org/1r8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8n RCSB], [https://www.ebi.ac.uk/pdbsum/1r8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DRTI_DELRE DRTI_DELRE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8n ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of a novel Kunitz (STI) family member, an inhibitor purified from Delonix regia seeds (DrTI), was solved by molecular replacement method and refined, respectively, to R(factor) and R(free) values of 21.5% and 25.3% at 1.75A resolution. The structure has a classical beta-trefoil fold, however, differently from canonical Kunitz type (STI) inhibitors, its reactive site loop has an insertion of one residue, Glu68, between the residues P1 and P2. Surprisingly, DrTI is an effective inhibitor of trypsin and human plasma kallikrein, but not of chymotrypsin and tissue kallikrein. Putative structural grounds of such specificity are discussed.
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===The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia===
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Crystal structure of the Kunitz (STI)-type inhibitor from Delonix regia seeds.,Krauchenco S, Pando SC, Marangoni S, Polikarpov I Biochem Biophys Res Commun. 2003 Dec 26;312(4):1303-8. PMID:14652016<ref>PMID:14652016</ref>
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{{ABSTRACT_PUBMED_14652016}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1r8n" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[1r8n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Delonix_regia Delonix regia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8N OCA].
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014652016</ref><references group="xtra"/>
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__TOC__
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[[Category: Delonix regia]]
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</StructureSection>
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[[Category: Krauchenco, S.]]
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[[Category: Marangoni, S.]]
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[[Category: Pando, S C.]]
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[[Category: Polikarpov, I.]]
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[[Category: Beta-trefoil fold]]
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[[Category: Delonix regia]]
[[Category: Delonix regia]]
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[[Category: Flamboyant]]
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[[Category: Large Structures]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Krauchenco S]]
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[[Category: Kunitz-type trypsin/kallikrein inhibitor]]
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[[Category: Marangoni S]]
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[[Category: Pando SC]]
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[[Category: Polikarpov I]]

Current revision

The Crystal Structure of the Kunitz (STI) Type Inhibitor from Seeds of Delonix regia

PDB ID 1r8n

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