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1ss6

From Proteopedia

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[[Image:1ss6.png|left|200px]]
 
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{{STRUCTURE_1ss6| PDB=1ss6 | SCENE= }}
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==Solution structure of SEP domain from human p47==
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<StructureSection load='1ss6' size='340' side='right'caption='[[1ss6]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ss6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SS6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ss6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ss6 OCA], [https://pdbe.org/1ss6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ss6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ss6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ss6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NSF1C_HUMAN NSF1C_HUMAN] Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1ss6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ss6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the human p47 SEP domain in a construct comprising residues G1-S2-p47(171-270) was determined by NMR spectroscopy. A structure-derived hypothesis about the domains' function was formulated and pursued in binding experiments with cysteine proteases. The SEP domain was found to be a reversible competitive inhibitor of cathepsin L with a Ki of 1.5 microM. The binding of G1-S2-p47(171-270) to cathepsin L was mapped by biochemical assays and the binding interface was investigated by NMR chemical shift perturbation experiments.
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===Solution structure of SEP domain from human p47===
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The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L.,Soukenik M, Diehl A, Leidert M, Sievert V, Bussow K, Leitner D, Labudde D, Ball LJ, Lechner A, Nagler DK, Oschkinat H FEBS Lett. 2004 Oct 22;576(3):358-62. PMID:15498563<ref>PMID:15498563</ref>
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{{ABSTRACT_PUBMED_15498563}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1ss6" style="background-color:#fffaf0;"></div>
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[[1ss6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SS6 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015498563</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ball, L J.]]
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[[Category: Large Structures]]
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[[Category: Buessow, K.]]
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[[Category: Ball LJ]]
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[[Category: Labudde, D.]]
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[[Category: Buessow K]]
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[[Category: Leidert, M.]]
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[[Category: Labudde D]]
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[[Category: Leitner, D.]]
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[[Category: Leidert M]]
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[[Category: Oschkinat, H.]]
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[[Category: Leitner D]]
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[[Category: Sievert, V.]]
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[[Category: Oschkinat H]]
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[[Category: Soukenik, M.]]
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[[Category: Sievert V]]
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[[Category: Nmr]]
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[[Category: Soukenik M]]
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[[Category: P47]]
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[[Category: Sep]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of SEP domain from human p47

PDB ID 1ss6

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