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1sjc

From Proteopedia

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[[Image:1sjc.png|left|200px]]
 
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{{STRUCTURE_1sjc| PDB=1sjc | SCENE= }}
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==x-ray structure of o-succinylbenzoate synthase complexed with N-succinyl methionine==
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<StructureSection load='1sjc' size='340' side='right'caption='[[1sjc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===x-ray structure of o-succinylbenzoate synthase complexed with N-succinyl methionine===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sjc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15134446}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SMG:N-SUCCINYL+METHIONINE'>SMG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjc OCA], [https://pdbe.org/1sjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sjc RCSB], [https://www.ebi.ac.uk/pdbsum/1sjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sjc ProSAT]</span></td></tr>
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[[1sjc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Amycolatopsis_sp. Amycolatopsis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJC OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/NSAR_AMYSP NSAR_AMYSP] Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). Can catalyze the racemization of a broad range of N-acylamino acids, including N-acetyl-D/L-methionine, N-propionyl-D/L-methionine, N-butyryl-D/L-methionine and N-chloroacetyl-L-valine (PubMed:7766084, PubMed:10194342, PubMed:14705949, PubMed:23130969). Also converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:14705949, PubMed:24955846). Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).<ref>PMID:10194342</ref> <ref>PMID:14705949</ref> <ref>PMID:23130969</ref> <ref>PMID:24955846</ref> <ref>PMID:7766084</ref> <ref>PMID:16740275</ref> <ref>PMID:24955846</ref>
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<ref group="xtra">PMID:015134446</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Amycolatopsis sp.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Garrett, J B.]]
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Check<jmol>
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[[Category: Gerlt, J A.]]
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<jmolCheckbox>
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[[Category: Holden, H M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sjc_consurf.spt"</scriptWhenChecked>
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[[Category: Rayment, I.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Taylor-Ringia, E A.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Thoden, J B.]]
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</jmolCheckbox>
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[[Category: Isomerase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sjc ConSurf].
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[[Category: Lyase]]
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<div style="clear:both"></div>
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[[Category: Racemase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Amycolatopsis sp]]
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[[Category: Large Structures]]
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[[Category: Garrett JB]]
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[[Category: Gerlt JA]]
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[[Category: Holden HM]]
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[[Category: Rayment I]]
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[[Category: Taylor-Ringia EA]]
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[[Category: Thoden JB]]

Current revision

x-ray structure of o-succinylbenzoate synthase complexed with N-succinyl methionine

PDB ID 1sjc

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