1sq9

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[[Image:1sq9.png|left|200px]]
 
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{{STRUCTURE_1sq9| PDB=1sq9 | SCENE= }}
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==Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination==
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<StructureSection load='1sq9' size='340' side='right'caption='[[1sq9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sq9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQ9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15152089}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sq9 OCA], [https://pdbe.org/1sq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1sq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sq9 ProSAT]</span></td></tr>
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[[1sq9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ9 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SKI8_YEAST SKI8_YEAST] Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.<ref>PMID:6371496</ref> <ref>PMID:3029964</ref> <ref>PMID:7739557</ref> <ref>PMID:9258672</ref> <ref>PMID:9482746</ref> <ref>PMID:10744028</ref> <ref>PMID:11532933</ref> <ref>PMID:11720286</ref> <ref>PMID:14671320</ref> <ref>PMID:15044957</ref> <ref>PMID:14992724</ref> <ref>PMID:16816949</ref>
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<ref group="xtra">PMID:015152089</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sq9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sq9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Madrona, A Y.]]
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[[Category: Madrona AY]]
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[[Category: Wilson, D K.]]
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[[Category: Wilson DK]]
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[[Category: Antiviral protein]]
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[[Category: Beta propeller]]
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[[Category: Beta-transducin repeat]]
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[[Category: Recombination]]
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[[Category: Wd repeat]]
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[[Category: Wd40 repeat]]
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Current revision

Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination

PDB ID 1sq9

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