1s4u

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[[Image:1s4u.png|left|200px]]
 
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{{STRUCTURE_1s4u| PDB=1s4u | SCENE= }}
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==Crystal Structure analysis of the beta-propeller protein Ski8p==
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<StructureSection load='1s4u' size='340' side='right'caption='[[1s4u]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal Structure analysis of the beta-propeller protein Ski8p===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4U FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15340168}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4u OCA], [https://pdbe.org/1s4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4u RCSB], [https://www.ebi.ac.uk/pdbsum/1s4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4u ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1s4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4U OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SKI8_YEAST SKI8_YEAST] Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.<ref>PMID:6371496</ref> <ref>PMID:3029964</ref> <ref>PMID:7739557</ref> <ref>PMID:9258672</ref> <ref>PMID:9482746</ref> <ref>PMID:10744028</ref> <ref>PMID:11532933</ref> <ref>PMID:11720286</ref> <ref>PMID:14671320</ref> <ref>PMID:15044957</ref> <ref>PMID:14992724</ref> <ref>PMID:16816949</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:015340168</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s4u ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Cheng, Z.]]
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[[Category: Cheng Z]]
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[[Category: Song, H.]]
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[[Category: Song H]]
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[[Category: Antiviral protein]]
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[[Category: Wd repeat]]
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Current revision

Crystal Structure analysis of the beta-propeller protein Ski8p

PDB ID 1s4u

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