1qzm

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[[Image:1qzm.png|left|200px]]
 
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{{STRUCTURE_1qzm| PDB=1qzm | SCENE= }}
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==alpha-domain of ATPase==
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<StructureSection load='1qzm' size='340' side='right'caption='[[1qzm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===alpha-domain of ATPase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qzm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZM FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15037242}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzm OCA], [https://pdbe.org/1qzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qzm RCSB], [https://www.ebi.ac.uk/pdbsum/1qzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qzm ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1qzm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZM OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:015037242</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Endopeptidase La]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qzm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qzm ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Botos, I.]]
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[[Category: Large Structures]]
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[[Category: Cherry, S.]]
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[[Category: Botos I]]
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[[Category: Gustchina, A.]]
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[[Category: Cherry S]]
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[[Category: Khalatova, A G.]]
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[[Category: Gustchina A]]
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[[Category: Maurizi, M R.]]
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[[Category: Khalatova AG]]
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[[Category: Melnikov, E E.]]
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[[Category: Maurizi MR]]
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[[Category: Rasulova, F S.]]
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[[Category: Melnikov EE]]
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[[Category: Rotanova, T V.]]
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[[Category: Rasulova FS]]
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[[Category: Tropea, J E.]]
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[[Category: Rotanova TV]]
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[[Category: Wlodawer, A.]]
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[[Category: Tropea JE]]
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[[Category: Aaa+ protein]]
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[[Category: Wlodawer A]]
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[[Category: Atp-dependent protease]]
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[[Category: Hydrolase]]
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[[Category: Oligomerization domain]]
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Current revision

alpha-domain of ATPase

PDB ID 1qzm

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