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1s4e

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[[Image:1s4e.png|left|200px]]
 
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{{STRUCTURE_1s4e| PDB=1s4e | SCENE= }}
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==Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium==
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<StructureSection load='1s4e' size='340' side='right'caption='[[1s4e]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s4e]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4e OCA], [https://pdbe.org/1s4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4e RCSB], [https://www.ebi.ac.uk/pdbsum/1s4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GAL1_PYRFU GAL1_PYRFU] Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Is very specific for its substrate, since it is not able to use D-glucose, D-fructose, D-mannose, 2-deoxy-D-glucose, and D-glucosamine as substrates.<ref>PMID:11978175</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s4e ConSurf].
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<div style="clear:both"></div>
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===Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium===
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==See Also==
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*[[Galactokinase|Galactokinase]]
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{{ABSTRACT_PUBMED_15003454}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1s4e]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4E OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:015003454</ref><references group="xtra"/>
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[[Category: Galactokinase]]
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Baker, P J.]]
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[[Category: Baker PJ]]
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[[Category: Barynin, V.]]
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[[Category: Barynin V]]
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[[Category: Geus, D de.]]
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[[Category: Glynn SE]]
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[[Category: Glynn, S E.]]
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[[Category: Hartley A]]
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[[Category: Hartley, A.]]
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[[Category: Reece RJ]]
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[[Category: Oost, J van der.]]
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[[Category: Rice DW]]
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[[Category: Reece, R J.]]
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[[Category: Sedelnikova SE]]
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[[Category: Rice, D W.]]
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[[Category: Timson DJ]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Verhees C]]
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[[Category: Timson, D J.]]
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[[Category: De Geus D]]
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[[Category: Verhees, C.]]
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[[Category: Van der Oost J]]
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[[Category: Ghmp kinase superfamily]]
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[[Category: P-loop]]
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[[Category: Transferase]]
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Current revision

Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium

PDB ID 1s4e

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