1s1e

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[[Image:1s1e.png|left|200px]]
 
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{{STRUCTURE_1s1e| PDB=1s1e | SCENE= }}
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==Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)==
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<StructureSection load='1s1e' size='340' side='right'caption='[[1s1e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1e OCA], [https://pdbe.org/1s1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1e RCSB], [https://www.ebi.ac.uk/pdbsum/1s1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCIP1_HUMAN KCIP1_HUMAN] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.<ref>PMID:10676964</ref> <ref>PMID:11423117</ref> <ref>PMID:12829703</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The family of calcium binding proteins called KChIPs associates with Kv4 family K(+) channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore the interaction between Kv4 subunits and KChIP1. Two regions in the Kv4.2 N terminus, residues 7-11 and 71-90, are necessary for KChIP1 modulation and interaction with Kv4.2. When inserted into the Kv1.2 N terminus, residues 71-90 of Kv4.2 are also sufficient to confer association with KChIP1. To provide a structural framework for these data, we solved the crystal structures of Kv4.3N and KChIP1 individually. Taken together with the mutagenesis data, the individual structures suggest that that the Kv4 N terminus is required for stable association with KChIP1, perhaps through a hydrophobic surface interaction, and that residues 71-90 in Kv4 subunits form a contact loop that mediates the specific association of KChIPs with Kv4 subunits.
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===Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)===
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Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.,Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lu Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ Neuron. 2004 Feb 19;41(4):587-98. PMID:14980207<ref>PMID:14980207</ref>
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{{ABSTRACT_PUBMED_14980207}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1s1e" style="background-color:#fffaf0;"></div>
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[[1s1e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1E OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:014980207</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bowlby, M R.]]
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[[Category: Large Structures]]
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[[Category: Carroll, K C.]]
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[[Category: Bowlby MR]]
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[[Category: Chanda, P.]]
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[[Category: Carroll KC]]
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[[Category: Edris, W.]]
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[[Category: Chanda P]]
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[[Category: Jow, F.]]
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[[Category: Edris W]]
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[[Category: Katz, A H.]]
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[[Category: Jow F]]
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[[Category: Kopsco, D C.]]
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[[Category: Katz AH]]
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[[Category: Lin, L.]]
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[[Category: Kopsco DC]]
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[[Category: Lu, Q.]]
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[[Category: Lin L]]
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[[Category: Malakian, K.]]
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[[Category: Lu Q]]
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[[Category: Megules, J.]]
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[[Category: Malakian K]]
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[[Category: Mosyak, L.]]
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[[Category: Megules J]]
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[[Category: Olland, S.]]
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[[Category: Mosyak L]]
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[[Category: Rhodes, K J.]]
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[[Category: Olland S]]
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[[Category: Scannevin, R H.]]
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[[Category: Rhodes KJ]]
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[[Category: Somers, W.]]
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[[Category: Scannevin RH]]
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[[Category: Stahl, M.]]
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[[Category: Somers W]]
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[[Category: Taylor, M.]]
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[[Category: Stahl M]]
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[[Category: Wang, K W.]]
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[[Category: Taylor M]]
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[[Category: Xu, W X.]]
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[[Category: Wang K-W]]
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[[Category: Xu, Z B.]]
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[[Category: Xu W-X]]
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[[Category: Calcium-binding protein]]
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[[Category: Xu Z-B]]
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[[Category: Ef-finger]]
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[[Category: Kchip]]
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[[Category: Kv channel-interacting protein]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)

PDB ID 1s1e

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