1r1b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1r1b" [edit=sysop:move=sysop])
Current revision (23:49, 27 December 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1r1b.png|left|200px]]
 
-
{{STRUCTURE_1r1b| PDB=1r1b | SCENE= }}
+
==EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE==
 +
<StructureSection load='1r1b' size='340' side='right'caption='[[1r1b]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1r1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1B FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1b OCA], [https://pdbe.org/1r1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1b RCSB], [https://www.ebi.ac.uk/pdbsum/1r1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1b ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/SYEP_CRIGR SYEP_CRIGR]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r1b ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these repeated motifs was also solved by NMR spectroscopy. One repeat is built around an antiparallel coiled-coil. Strikingly, the conserved lysine and arginine residues form a basic patch on one side of the structure, presenting a suitable docking surface for nucleic acids. Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor.
-
===EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE===
+
A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases.,Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942<ref>PMID:10654942</ref>
-
{{ABSTRACT_PUBMED_10654942}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1r1b" style="background-color:#fffaf0;"></div>
-
[[1r1b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:010654942</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
-
[[Category: Berthonneau, E.]]
+
[[Category: Large Structures]]
-
[[Category: Birlirakis, N.]]
+
[[Category: Berthonneau E]]
-
[[Category: Cahuzac, B.]]
+
[[Category: Birlirakis N]]
-
[[Category: Guittet, E.]]
+
[[Category: Cahuzac B]]
-
[[Category: Mirande, M.]]
+
[[Category: Guittet E]]
-
[[Category: Ligase]]
+
[[Category: Mirande M]]
-
[[Category: Protein transcription]]
+

Current revision

EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1r1b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r1b"
Personal tools