1s66

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[[Image:1s66.png|left|200px]]
 
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{{STRUCTURE_1s66| PDB=1s66 | SCENE= }}
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==Crystal structure of heme domain of direct oxygen sensor from E. coli==
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<StructureSection load='1s66' size='340' side='right'caption='[[1s66]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of heme domain of direct oxygen sensor from E. coli===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S66 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15005609}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s66 OCA], [https://pdbe.org/1s66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s66 RCSB], [https://www.ebi.ac.uk/pdbsum/1s66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s66 ProSAT]</span></td></tr>
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[[1s66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S66 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DOSP_ECOLI DOSP_ECOLI] Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Has very poor PDE activity on cAMP (PubMed:15995192) but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed:11970957). Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits.<ref>PMID:20553324</ref>
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<ref group="xtra">PMID:015005609</ref><ref group="xtra">PMID:018980385</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s6/1s66_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s66 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Kang, C H.]]
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[[Category: Large Structures]]
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[[Category: Park, H J.]]
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[[Category: Kang CH]]
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[[Category: Satterlee, J D.]]
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[[Category: Park HJ]]
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[[Category: Suquet, C.]]
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[[Category: Satterlee JD]]
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[[Category: Do]]
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[[Category: Suquet C]]
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[[Category: Heme protein]]
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[[Category: Oxygen sensor]]
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[[Category: Oxygen storage-transport complex]]
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[[Category: Pa]]
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Current revision

Crystal structure of heme domain of direct oxygen sensor from E. coli

PDB ID 1s66

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