1rq1

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[[Image:1rq1.png|left|200px]]
 
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{{STRUCTURE_1rq1| PDB=1rq1 | SCENE= }}
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==Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell==
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<StructureSection load='1rq1' size='340' side='right'caption='[[1rq1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RQ1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15163408}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NEN:1-ETHYL-PYRROLIDINE-2,5-DIONE'>NEN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rq1 OCA], [https://pdbe.org/1rq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rq1 RCSB], [https://www.ebi.ac.uk/pdbsum/1rq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rq1 ProSAT]</span></td></tr>
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[[1rq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RQ1 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/ERO1_YEAST ERO1_YEAST] Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Also able to oxidize directly the PDI related protein MPD2. Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins. Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress.<ref>PMID:9659913</ref> <ref>PMID:9659914</ref> <ref>PMID:10549279</ref> <ref>PMID:11090354</ref> <ref>PMID:12453408</ref>
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<ref group="xtra">PMID:015163408</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/1rq1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rq1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Fass, D.]]
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[[Category: Fass D]]
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[[Category: Gross, E.]]
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[[Category: Gross E]]
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[[Category: Kaiser, C A.]]
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[[Category: Kaiser CA]]
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[[Category: Kastner, D B.]]
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[[Category: Kastner DB]]
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[[Category: Cxxcxxc]]
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[[Category: Disulfide bond]]
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[[Category: Flavoenzyme]]
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[[Category: Oxidoreductase]]
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Current revision

Structure of Ero1p, Source of Disulfide Bonds for Oxidative Protein Folding in the Cell

PDB ID 1rq1

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