1rr9

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[[Image:1rr9.png|left|200px]]
 
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{{STRUCTURE_1rr9| PDB=1rr9 | SCENE= }}
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==Catalytic domain of E.coli Lon protease==
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<StructureSection load='1rr9' size='340' side='right'caption='[[1rr9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Catalytic domain of E.coli Lon protease===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rr9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RR9 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14665623}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rr9 OCA], [https://pdbe.org/1rr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1rr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rr9 ProSAT]</span></td></tr>
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[[1rr9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RR9 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref>
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<ref group="xtra">PMID:014665623</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Endopeptidase La]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rr/1rr9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rr9 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Botos, I.]]
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[[Category: Large Structures]]
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[[Category: Cherry, S.]]
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[[Category: Botos I]]
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[[Category: Dauter, Z.]]
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[[Category: Cherry S]]
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[[Category: Gustchina, A.]]
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[[Category: Dauter Z]]
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[[Category: Khalatova, A G.]]
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[[Category: Gustchina A]]
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[[Category: Maurizi, M R.]]
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[[Category: Khalatova AG]]
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[[Category: Melnikov, E E.]]
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[[Category: Maurizi MR]]
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[[Category: Rotanova, T V.]]
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[[Category: Melnikov EE]]
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[[Category: Tropea, J E.]]
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[[Category: Rotanova TV]]
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[[Category: Wlodawer, A.]]
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[[Category: Tropea JE]]
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[[Category: Atp-dependent protease]]
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[[Category: Wlodawer A]]
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[[Category: Catalytic dyad ser-ly]]
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[[Category: Hydrolase]]
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Current revision

Catalytic domain of E.coli Lon protease

PDB ID 1rr9

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