1t3j

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[[Image:1t3j.png|left|200px]]
 
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{{STRUCTURE_1t3j| PDB=1t3j | SCENE= }}
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==Mitofusin domain HR2 V686M/I708M mutant==
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<StructureSection load='1t3j' size='340' side='right'caption='[[1t3j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Mitofusin domain HR2 V686M/I708M mutant===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3J FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15297672}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [https://pdbe.org/1t3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB], [https://www.ebi.ac.uk/pdbsum/1t3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3j ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1t3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/MFN1_MOUSE MFN1_MOUSE] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:12527753</ref> <ref>PMID:15297672</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:015297672</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3j ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chan, D C.]]
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[[Category: Chan DC]]
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[[Category: Chen, H.]]
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[[Category: Chen H]]
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[[Category: Detmer, S A.]]
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[[Category: Detmer SA]]
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[[Category: Kaiser, J T.]]
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[[Category: Kaiser JT]]
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[[Category: Koshiba, T.]]
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[[Category: Koshiba T]]
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[[Category: McCaffery, J M.]]
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[[Category: McCaffery JM]]
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[[Category: Coiled coil antiparallel]]
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[[Category: Dimer]]
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[[Category: Membrane protein]]
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Current revision

Mitofusin domain HR2 V686M/I708M mutant

PDB ID 1t3j

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OCA

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