1tr9

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[[Image:1tr9.gif|left|200px]]<br /><applet load="1tr9" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tr9, resolution 1.80&Aring;" />
 
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'''Structure of beta-hexosaminidase from Vibrio cholerae'''<br />
 
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==About this Structure==
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==Structure of beta-hexosaminidase from Vibrio cholerae==
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1TR9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Active as [http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR9 OCA].
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<StructureSection load='1tr9' size='340' side='right'caption='[[1tr9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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[[Category: Beta-N-acetylhexosaminidase]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1tr9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TR9 FirstGlance]. <br>
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[[Category: Vibrio cholerae]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Burley, S K.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Gorman, J.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tr9 OCA], [https://pdbe.org/1tr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tr9 RCSB], [https://www.ebi.ac.uk/pdbsum/1tr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tr9 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1tr9 TOPSAN]</span></td></tr>
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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</table>
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[[Category: Shapiro, L.]]
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== Function ==
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[[Category: beta-alpha barrel]]
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[https://www.uniprot.org/uniprot/NAGZ_VIBCH NAGZ_VIBCH] Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Plays a role in beta-lactam antibiotic resistance via its role in generating anhydro-N-acetylmuramic acid-linked peptides; these peptides function as signaling molecules that induce high-level expression of the beta-lactamase AmpC.<ref>PMID:24009110</ref> <ref>PMID:17439950</ref> <ref>PMID:19499593</ref>
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[[Category: beta-hexosaminidase]]
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== Evolutionary Conservation ==
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[[Category: new york structural genomix research consortium]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: nysgxrc]]
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Check<jmol>
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[[Category: protein structure initiative]]
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<jmolCheckbox>
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[[Category: psi]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tr/1tr9_consurf.spt"</scriptWhenChecked>
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[[Category: structural genomics]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tr9 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:16:31 2008''
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==See Also==
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*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
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*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
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*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Vibrio cholerae]]
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[[Category: Burley SK]]
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[[Category: Gorman J]]
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[[Category: Shapiro L]]

Current revision

Structure of beta-hexosaminidase from Vibrio cholerae

PDB ID 1tr9

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